Traveling raccoon con artist, RJ (Willis), arrives in a woods outside a human city in the Midwest, excited about the wonders that living near humans can bring hungry animals. What he finds, however, is an Amish-like community that is deathly afraid of humans, after their leader, Vern the tortoise (Shandling), has an encounter with human boys that terrifies him.

Encouraged by RJ, however, the animals slowly venture over the hedge that separates them from the brand new suburban development that appeared over the winter while they were sleeping, and what RJ shows them is a whole new world where humans leave tin cans full of fish and other food in big canisters, ripe for the taking. As they get closer and closer to humans, however, their comfortable lives in the woods appears to be threatened.