The classic story of loyalty, trust, and sacrifice comes to life in this live-action adaptation. Fern (Dakota Fanning) is one of only two living beings who sees that Wilbur is a special animal as she raises him, the runt of the litter, into a terrific and radiant pig. As Wilbur moves into a new barn, he begins a second profound friendship with the most unlikely of creatures - a spider named Charlotte - and their bond inspires the animals around them to come together as a family.

When the word gets out that Wilbur's days are numbered, it seems that only a miracle will save his life. A determined Charlotte - who sees miracles in the ordinary - spins words into her web in an effort to convince the farmer that Wilbur is "some pig" and worth saving.